M/s submitted to
Chemistry in Britain.
Please address all correspondence to:
Prof Mark J Winter
Department of Chemistry
The University of
Sheffield
Sheffield S3 7HF, UK.
M.Winter@Sheffield.ac.uk
Modification Date: Wednesday, March 29, 1995
Box3: Hyperactive Molecules
A two-dimensional structure diagram is not always appropriate in conveying
subtle three dimensional information. Here, one really wants the reader to be
able to rotate the molecule freely, as if they were holding a physical model of
the molecule in their hands. This can be readily implemented by storing the
molecular coordinates on the World-Wide Web server in a standard format such as
"pdb" and activating them by a hyperlink using a mechanism known as chemical
MIME (Multipurpose Internet Mail Extension).[4] When the hyperlink is activated, the
coordinates are transmitted to a local viewing program selected by the user,
where they can be manipulated by the reader. The diagram in Box 2 contains such
a hyperlink to the final three dimensional coordinates of papuamine. By
clicking in this region, the user can verify for themselves the stereochemical
features of this natural product. Another example of a "hyperactive" molecule
might be associated with the pages of an electronic journal;